Exploring the Effects of Reiki on Cancer Cell Growth

 

Research Overview

CRR director Patricia DeLeon (left), an Associate Professor of Biology and Nutrition at the Borough of Manhattan Community College, with assistance from CRR director Ann Thompson (right), a Certified Medical Reiki Master, is researching the impact of Reiki on the growth of human cancer cells.

Experimental Approach and Findings

The initial phase of the study consisted of three rounds of experiments, in which breast cancer cells received either Reiki or sham Reiki treatments. Across all three rounds, the results consistently showed that cells receiving Reiki exhibited reduced growth compared to the control group. Both Reiki and placebo groups displayed similar outcomes when treated with a single dose—15 minutes per day over three days. However, when the treatment frequency increased to two 15-minute sessions daily, a clear distinction emerged: the Reiki-treated cells demonstrated a more pronounced reduction in growth compared to those receiving the placebo. The latest set of experiments aimed to gather further statistical data, seeking a p-value of less than 0.05, and to assess the sustainability of Reiki’s effects over time.

Next Steps and Support 

Building on these promising results, the researchers plan to replicate the experiments using nematode C. elegans. This will allow the researchers to collect in vivo data and extend their findings beyond in vitro studies. Continued support is essential to keep this research moving forward. Help advance this important work and donate to CRR today.

Supporting Patient Care and Stress Management with Reiki at Duke University Hospital

After spending a decade in oncology nursing, Nicole Mouser recognized a critical need for integrative health practices. She now brings this vision to the inpatient bedside, utilizing holistic nursing theories and techniques — such as Reiki, mindfulness, EFT/tapping, and acupressure, among others — to support patient care and stress management.

Nicole Mouser RN, BSN, CSNIV, HNB-BC, HWNC-BC is a Board-Certified Holistic Health and Wellness Nurse Coach and Reiki Master Practitioner (RMT) with over 15 years of nursing experience. She currently serves as Stress Management Clinician for Duke University Hospital within the DUHS Advanced Practice Nursing department.

The 30-minute webinar will include a 10-minute live Q&A with the audience. All participants will receive a webinar recording, and all CRR associate and professional members will be automatically registered.

Register here.

All CRR past webinars may be purchased in video on demand format here.

CRR Paper Links Subjective Reiki Experiences to Changes in Physiological and Psychological Health

CRR, in collaboration with World Reiki Research and Harvard University, has just published the results of a landmark study evaluating whether specific subjective Reiki experiences are associated with changes in health-related symptoms using regression and mediation analyses. Ninety-nine Reiki practitioners had clients complete a survey before and after 1,284 Reiki (60-minute in-person) sessions.

Linear regression analyses explored associations between subjective Reiki experiences and changes in well-being, pain, and anxiety, while controlling for age and gender. Mediation models tested whether pain and anxiety changes mediated the relationship between subjective Reiki experiences and improvements in well-being.

Experiencing positive emotions was significantly associated with higher well-being and reduced anxiety, and experiencing such body sensations as tingling or warmth was significantly associated with greater pain relief. There was a significant indirect effect of body sensations on well-being via pain relief, a significant indirect effect of positive emotions on well-being via anxiety reduction, and a significant indirect effect of emotional release on well-being via anxiety reduction.

The results suggest that the subjective experience of receiving Reiki is related to changes in different psychological and physical health symptoms. More work is needed to confirm these findings while addressing the limitations of the current study.

This study is a novel contribution to biofield therapy research in several ways. First, it explores how Reiki works through specific psychological and physical pathways through employing a mediation analysis to quantify both indirect and direct effects, providing robust empirical support for the underlying mechanisms. Second, this study integrates both psychological (anxiety) and physical (pain) mediators, offering a more holistic understanding of Reiki’s effects. Third, it offers a framework to provide evidence for Reiki’s acceptance in clinical settings by linking subjective experiences to measurable changes in physiological and psychological health. Importantly, by identifying how Reiki may exert its effects (e.g., through pain relief or anxiety reduction), this analysis begins to answer the “why” question often missing in complementary and integrative medicine research. Understanding not only whether Reiki improves outcomes, but also how and why it does so, is central to advancing the evidence base for complementary and integrative medicine. Most prior Reiki research has demonstrated symptom improvements without clarifying the underlying processes. By employing mediation analysis, the present study provides a step toward explaining the why. When participants experience physical sensations (such as warmth or tingling), this is linked to reductions in pain, which in turn enhances overall well-being. Similarly, when participants experience positive emotions or emotional release, these appear to lower anxiety, which then improves well-being. In this way, the “how” is represented by the mediating pathways (pain relief, anxiety reduction), while the “why” lies in the role of subjective experience as the active ingredient that drives those changes. This shift from describing Reiki’s effects to explaining them is a step toward building evidence and integrating Reiki into broader models of health care.

Congratulations to the authors: CRR Research Assistant Elisenda Cama i Gibernau, CRR Director Akleema Ali and CRR President Natalie Dyer.

Read the paper here.

CRR Webinars Available in VOD Format

 

All CRR past webinars — including  Jane Van de Velde’s Reiki For The Cancer Community: Offering Reiki Programs To People Dealing With a Serious Illness — may be purchased in video on demand format here.

Past webinars are available at no charge to associate and professional members here.

Advocating for Scientific Rigor in Reiki Research

As part of CRR’s efforts to promote scientific rigor in Reiki research, we’ve successfully connected with the scientific journals Epilepsy & Behavior, Journal of Paediatrics and Child Health, and Journal of Nursing and Education.

CRR director Ann Baldwin authored three letters to the editors, referencing Biofield Therapies: Guidelines for Reporting Clinical Trials which outlines the steps required to produce scientifically sound research papers. Since the guidelines are applicable to designing studies as well, CRR recommended the three journals augment their “Instructions for Authors” with a copy of, or reference to, these guidelines.

All three letters have been published:

CRR’s mission is to validate and foster the acceptance of Reiki biofield therapy as an integrative healthcare practice. Only rigorous, scientifically robust studies can provide the evidence necessary to support the use of this low risk, non-invasive modality in clinical settings.

Biofield Therapies Research Overview

The recent open access paper by Meredith Sprengel et al. titled Biofield Therapies Clinical Research Landscape: A Scoping Review and Interactive Evidence Map published in the Journal of Integrative and Complementary Medicine provides a comprehensive overview of the current state of clinical research on biofield therapies – including Reiki.

The authors conducted a scoping review to map the existing evidence on biofield therapies and created an interactive evidence map to visually represent the findings. The review aimed to identify the diverse populations, health conditions and outcomes that have been studied in relation to biofield therapies, the methodologies used, and the geographical distribution of the research.

Key findings from the review of 353 peer-reviewed studies published in English (including 96 Reiki studies) indicate that biofield therapies have been explored across a wide range of health conditions, including cancer, pain management, mental health disorders, cardiovascular diseases, and chronic illnesses. Most studies employed randomized controlled trials (RCTs) and observational designs, with varying levels of methodological rigor. While some studies reported positive outcomes, such as reduced pain, improved mood, and enhanced quality of life, others showed mixed or inconclusive results.

Interactive Evidence Map

The publicly available, interactive Biofield Science Evidence Map created by the authors serves as a valuable tool for researchers, practitioners, and policymakers. Intended to be updated yearly, it allows users to filter and navigate through the research landscape by health condition, study design, and outcome measure, providing a clear and accessible way to understand the scope and quality of biofield therapy research.

The paper also highlights several gaps and challenges in the current research landscape. These include the need for more high-quality, large-scale RCTs, greater standardization of biofield therapy protocols, and improved reporting of intervention details. Additionally, the authors call for increased collaboration and interdisciplinary approaches to advance the scientific understanding of biofield therapies and their potential mechanisms of action.

Overall, the scoping review and evidence map presented in this paper offer a comprehensive and detailed overview of the clinical research landscape for biofield therapies. They underscore the importance of continued research in this field to validate the efficacy of these therapies and to adopt them as integrative care options in allopathic medicine.

Current Status of Reiki Research 2024

By Ann Baldwin, PhD, Professor Emerita of Physiology, University of Arizona; Director of Mind-Body-Science; and Editor-in-Chief, Center for Reiki Research

According to the NIH National Center for Complementary and Integrative Health web site entry for Reiki (last updated in December 2018):

“Reiki hasn’t been clearly shown to be effective for any health-related
purpose. It has been studied for a variety of conditions, including pain,
anxiety, and depression, but most of the research has not been of high
quality, and the results have been inconsistent.”

The evidence suggests otherwise.

As of July 2024, there are 140 Reiki research papers that have been published in peer-reviewed scientific journals, but most are pilot studies with small numbers (fewer than 20) of participants per group, and many do not include appropriate control groups. For these reasons, the medical profession often dismisses these studies as inconclusive. A closer examination of overlapping data from some of the stronger pilot studies and the 13 larger scale clinical trials with 30 or more participants per group (see list below) supports the ability of Reiki to reduce anxiety and pain, and suggests its usefulness to induce relaxation, improve fatigue, burn-out and depressive symptoms, and strengthen overall wellbeing.

Four published literature reviews of Reiki research (see list below)  state that there is sufficient evidence to conclude that Reiki is more effective than placebo in reducing pain and anxiety and that it has the potential for managing chronic health conditions and postoperative recovery. The research on Reiki’s effectiveness is promising, but more large studies are needed to convince medical professionals to invest their time, finances, and effort in researching how Reiki can serve as an adjunct to allopathic medicine. Only through successful, scientifically robust, large-scale clinical trials will the decision-makers at top scientific and medical institutions be convinced to support the widespread use of Reiki in hospitals, clinics, and hospices.

Published Reiki clinical trials with at least 30 participants per group:

  1. Gillespie E.A., Gillespie B.W., Stevens M.J. (2007). Painful Diabetic Neuropathy: Impact of an Alternative ApproachDiabetes Care. 2007;30:999–1001.
  2. Catlin A., Taylor-Ford R.L. (2011). Investigation of Standard Care Versus Sham Reiki Placebo Versus Actual Reiki Therapy to Enhance Comfort and Well-Being in a Chemotherapy Infusion CenterOncol Nurse Forum. 2011;38:E212–E220.
  3. Kurebayashi, L.F.S., Turrini, R.N.T., Souza, T.P.B.D., Takiguchi, R.S., Kuba, G., & Nagumo, M.T. (2016). Massage and Reiki Used to Reduce Stress and Anxiety: Randomized Clinical Trial. Revista latino-americana de enfermagem, 24. 
  4. Charkhandeh, M., Talib, M.A., & Hunt, C.J. (2016). The Clinical Effectiveness of Cognitive Behavior Therapy and an Alternative Medicine Approach in Reducing Symptoms of Depression in Adolescents. Psychiatry Research, 239, 325-330. 
  5. Chirico A., D’aiuto G., Penon A., et al. (2017). Self-Efficacy for Coping with Cancer Enhances the Effect of Reiki Treatments During the Pre-Surgery Phase of Breast Cancer Patients. Anticancer Research, 37(7), 3657-3665.
  6. Vergo, M.T., Pinkson, B.M., Broglio, K., Li, Z., & Tosteson, T.D. (2018). Immediate Symptom Relief After a First Session of Massage Therapy or Reiki in Hospitalized Patients: A 5-year Clinical Experience From a Rural Academic Medical Center. The Journal of Alternative and Complementary Medicine, 24(8), 801-808. 
  7. Dyer N.L., Baldwin A.L., Rand W.L. (2019). A Large-Scale Effectiveness Trial of Reiki for Physical and Psychological Health. The Journal of Alternative and Complementary Medicine, 25(12), 1156-1162. 
  8. Jurkovich P., Watson S. (2020). Implementation of a Volunteer Reiki Program at an Academic Medical Center in the Midwest. Journal of Holistic Nursing, 0898010120907734.
  9. Topdemir E.A., Saritas S. (2020). The Effect of Preoperative Reiki Application on Patient Anxiety Levels. EXPLORE, 17(1), 50-54.
  10. Bondi, A., Morgan, T., & Fowler, S.B. (2020). Effects of Reiki on Pain and Anxiety in Women Hospitalized for Obstetrical- and Gynecological-Related Conditions. Journal of Holistic Nursing, 0898010120936437. 
  11. Buyukbayram Z., Saritas S.C. (2020). The Effect of Reiki and Guided Imagery Intervention on Pain and Fatigue in Oncology Patients: A Non-Randomized Controlled Study. EXPLORE, 17(1), 22-26.
  12. Utli H., Yağmur Y. (2021). The Effects of Reiki and Back Massage on Women’s Pain and Vital Signs Post Abdominal Hysterectomy: A Randomized Controlled Trial. EXPLORE (NY), 0000, 1-8. Doi. https://doi.org/10.1016/j.explore.2021.07.004.
  13. Utli, H., & Birgul, D.B. (2022). The Effect of Reiki on Anxiety, Stress, and Comfort Levels Before Gastrointestinal Endoscopy: A Randomized Sham-Controlled Trial. Journal of Peri-Anesthesia Nursing, 00(00), 1-8. doi: https://doi.org/10.1016/j.jopan.2022.08.01.

Published Reiki research literature reviews:

  1. McManus, D.E. (2017). Reiki Is Better Than Placebo and Has Broad Potential as a Complementary Health Therapy. Journal of Evidence-Based Complementary & Alternative Medicine, 2017 Oct; 22(4): 1051–1057. doi: 10.1177/2156587217728644
  2. Morero, J.A.P., de Souza Pereira, S., Esteves, R.B., Cardosos, L. (2021). Effects of Reiki on Mental Health Care: A Systematic Review. Holistic Nursing Practice, 2021 Jul-Aug;35(4):191-198. doi: 10.1097/HNP.0000000000000456.
  3. Zadro, S., Stapleton, P. (2022). Does Reiki Benefit Mental Health Symptoms Above Placebo? Front Psychology, 2022 Jul 12:13:897312. doi:10.3389/fpsyg.2022.897312. eCollection 2022.
  4. Humphreys, E., Cabrera, E., Downey Luhrmann, S. (2023). The Effectiveness of Treating Anxiety With Reiki. Journal of Behavior TherapyDOI:10.14302/issn2474-9273.jbtm-23-4712 Corpus ID: 264051702